You may want to move this to the discussion board.
For me, the people who have changed the framework through which we view science are the key people. There are several that come to mind...
Darwin, evolution by means of natural selection.
Newton, laws of motion.
Mendeleev, devising the Periodic Table.
And for medical doctors, Pasteur, germ theory of disease.
These people changed the way things that were already known were viewed and applied, as well as enabled further discoveries in their fields. There have been many who made extraordinary discoveries, but these people changed how we looked at those discoveries. Just imagine if we still thought disease was still caused by evil spirits.
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